One of two U.S. Senate seats representing the state of Mississippi. Senators serve six-year terms and represent the entire state population.


7 candidates filed, 3 active for the 2026 Senate election in Mississippi. Party primary on Mar 10, 2026. General election on Nov 3, 2026.
| Year | Winner | Result | Runner-Up | Total Votes |
|---|---|---|---|---|
| 2024 | Roger F. Wicker R | 62.8% | 1,215,401 | |
| 2020 | Cindy Hyde-Smith R | 54.1% | 1,311,354 | |
| 2018 | Roger F. Wicker R | 58.5% | 936,215 | |
| 2014 | Thad Cochran R | 59.9% | 631,858 | |
| 2012 | Roger F. Wicker R | 57.2% | 1,241,568 | |
| 2008 | Thad Cochran R | 61.4% | 1,247,026 | |
| 2006 | Trent Lott R | 63.6% | 610,921 | |
| 2002 | Thad Cochran R | 84.6% | 630,495 | |
| 2000 | Trent Lott R | 65.9% | 994,144 | |
| 1996 | Thad Cochran R | 71.0% | 878,662 | |
| 1994 | Trent Lott R | 68.8% | 608,085 | |
| 1990 | Thad Cochran R | 100.0% | 274,244 | |
| 1988 | Trent Lott R | 53.9% | 946,719 | |
| 1984 | Thad Cochran R | 60.9% | 952,240 | |
| 1982 | John C. Stennis D | 64.2% | 645,026 |