Sage Bionetworks is a nonprofit research organization founded in 2009 to accelerate the translation of data-intensive science into medicine. Drawing on our roots in open science, we develop and apply community practices that address barriers that limit the implementation and interpretation of computational biomedical research. We are modernizing how biomedical data and insights are collected, managed, and used, and we partner with scientists in academia, industry and the nonprofit sectors to ensure that data-intensive science programs lead to actionable results.