The AFFECT Human Rights in Venezuela Act directs the U.S. State Department to use American influence at the United Nations to extend and support an independent international fact-finding mission investigating human rights violations in Venezuela, including alleged crimes against humanity committed by Venezuelan military and intelligence agencies since 2014. The bill affects U.S. foreign policy toward Venezuela and aims to hold Venezuelan government officials accountable for documented abuses such as torture, extrajudicial executions, and enforced disappearances. The legislation authorizes the U.S. to encourage international backing for the fact-finding mission, provide investigative assistance within UN rules, and urge the UN to take broader action on Venezuela's humanitarian crisis and political prisoners. The Secretary of State must submit progress reports to Congress within 90 days of the bill's enactment and annually thereafter until the fact-finding mission's mandate expires. The bill does not specify new funding but calls for the State Department to advocate for continued UN support and international donor contributions to address Venezuela's humanitarian needs.