The FACTS Act establishes a federal program to combat synthetic opioid misuse among young people through school-based education and prevention efforts. The bill authorizes the Department of Health and Human Services to award three-year grants to up to 25 partnerships between schools and public health agencies to develop evidence-based prevention programs, professional development for school staff, peer counseling initiatives, and community awareness campaigns focused on fentanyl and other synthetic opioids. The legislation also creates an interagency task force to coordinate federal responses and identify best practices, requires schools receiving federal funding to address synthetic opioid prevention in their educational plans, and mandates improvements to national surveys and data collection systems to better track youth exposure to synthetic opioids. The bill authorizes unspecified funding for fiscal years 2025 through 2027 for the grant program, with an additional five percent of funds reserved for evaluation and technical assistance to applicants, particularly those in rural and underserved areas.