The Health Opportunities to Promote Equity Act, or HOPE Act, modifies the health profession opportunity grant program under Social Security law to ensure that grants are distributed more broadly across the country. Specifically, the bill requires the Department of Health and Human Services to award grants to at least two eligible organizations in every state and the District of Columbia during each grant cycle, provided there are enough qualified applicants. The legislation affects organizations and training programs that work to prepare low-income individuals for careers in health professions. The bill requires the Secretary of Health and Human Services to submit annual reports to Congress detailing the number of grant applications received, approved, and how grants were distributed, particularly in states with fewer than two eligible applicants. The amendments take effect on October 1, 2023.