The NRC Mission Alignment Act directs the Nuclear Regulatory Commission to update its mission statement within 90 days to reflect that nuclear licensing and regulation should be conducted efficiently without unnecessarily limiting nuclear energy's potential to improve public welfare and provide societal benefits. The bill specifically amends the Energy Reorganization Act of 1974 to establish clear procedures for the Director of Nuclear Reactor Regulation to create and maintain standardized techniques and guidance for evaluating nuclear reactor license applications, ensuring reviews are efficient, timely, and predictable while maintaining safety and security standards. The bill affects the NRC's internal operations and regulatory approach toward the nuclear energy industry. The legislation requires the NRC to submit a report to Congress describing the updated mission statement and the guidance it will provide staff to implement the changes. No specific funding amounts or appropriations are mentioned in the bill.