The Protect Black Women and Girls Act would establish a federal Interagency Task Force led by the Attorney General to examine and improve conditions for Black women and girls across education, economic development, healthcare, housing, and the criminal justice system. The task force would bring together representatives from multiple federal agencies including Health and Human Services, Education, Labor, Justice, and Housing and Urban Development, along with community organizations, to identify effective policies and recommend improvements to federal, state, and local programs. Within two years of the bill's enactment, the task force would submit recommendations to Congress and state leaders on specific initiatives, such as restorative justice programs in schools, support for Black women entrepreneurs and workers, expanded mental health services, and reforms to reduce incarceration. Additionally, the U.S. Commission on Civil Rights would be required to conduct an annual comprehensive study examining disparities affecting Black women and girls in areas including maternal mortality, wage gaps, police use of force, sex trafficking, and the school-to-prison pipeline. The bill does not specify dedicated federal funding amounts but calls for the task force to identify existing programs and funding mechanisms to support its recommendations.