The Preventing Adverse Childhood Experiences Act establishes a federal grant program to help states, territories, tribal nations, and local governments develop programs that prevent adverse childhood experiences and promote positive ones. The bill directs the Centers for Disease Control and Prevention to award grants to organizations for carrying out evidence-based prevention strategies, improving data collection on childhood trauma, and addressing how overdose and mental health crises intersect with childhood adversity. Additionally, the legislation requires the CDC to conduct research studies examining the relationship between specific adverse childhood experiences and negative health outcomes, with particular attention to historical trauma in communities like American Indians and Alaska Natives. The bill authorizes the Secretary of Health and Human Services to provide technical assistance to grant recipients and requires annual reporting to Congress on program performance. While the legislation does not specify a total funding amount in the text provided, it establishes an ongoing federal commitment to understanding and preventing childhood trauma as a public health priority.