The American Nuclear Workforce Act directs the Secretary of Energy to establish an initiative encouraging states to promote nuclear science and technology education at schools located near nuclear power plants or reactor development facilities. The bill affects secondary schools and colleges within approximately 25 miles of operating nuclear plants or reactor developer headquarters, as well as any other schools the Energy Secretary deems appropriate. The initiative includes encouraging colleges to offer nuclear-related degrees in fields like nuclear engineering and radiochemistry, facilitating plant tours and industry outreach, establishing a mentorship program pairing nuclear industry professionals with students, and promoting the use of campus research reactors for workforce preparation. The legislation directs these efforts to be coordinated with the Department of Energy's existing Nuclear Energy University Program and does not specify new federal funding amounts or implementation timelines.