This bill directs the Department of Health and Human Services to identify and evaluate evidence-based mental health and social-emotional interventions that can be used in Head Start and Early Head Start programs, which serve low-income preschool-age children nationwide. The Secretary must complete an initial review of effective interventions, best practices, and staff training programs within two years, with updates every five years thereafter, and must consult with experts and seek public input throughout the process. The bill authorizes grants to Head Start agencies to implement these interventions across diverse geographic areas and requires evaluation of whether the programs effectively improve child outcomes and produce long-term savings. The legislation also allows funding for up to five university-based Best Practice Centers to train future Head Start staff in delivering these interventions. The bill authorizes $100 million in federal funding over ten fiscal years from 2025 through 2034 to support program implementation, evaluation, and training center development.