The No PREJUDICE Act prohibits the Department of Homeland Security from using federal funds to detain, arrest, or investigate individuals based on race, ethnicity, religion, national origin, gender identity, sexual orientation, or language use, including speaking Spanish or English with an accent. The bill also prevents DHS from targeting people based on their location at employment sites like bus stops or car washes, or their participation in particular jobs or hobbies. Aliens facing removal proceedings can request a hearing in federal district court to challenge whether DHS violated these prohibitions, and if a judge finds a violation occurred, the removal case must be dismissed. If the judge finds no violation, the case returns to immigration court for continued removal proceedings. This legislation directly affects DHS enforcement officers and agents as well as immigrants and foreign nationals subject to immigration enforcement actions.