The BEDROCK Act directs the Secretary of Commerce to strengthen U.S. biomanufacturing competitiveness by identifying vulnerabilities in domestic production capacity and supply chains for critical biomanufacturing inputs while increasing transparency in federal regulatory processes. The legislation establishes a new senior Commerce Department official to lead these efforts, requiring biennial assessments of U.S. biomanufacturing capacity, foreign adversaries' influence, and commercialization obstacles, along with a prioritized action plan and public web portal of federal resources. Within 180 days of enactment, the FDA and EPA must each designate points of contact to help private companies navigate regulations for biomanufactured products and critical inputs. The Commerce Secretary must submit biennial reports to Congress on biomanufacturing assessments, action plans, and regulatory compliance practices, with all reporting requirements set to expire after five years. The bill protects confidential business information and supply-chain vulnerability data from public disclosure while allowing companies to identify sensitive submissions.