This bill requires the Department of Health and Human Services to create a centralized online repository on opendata.hhs.gov containing all publicly available health datasets generated or maintained by the department. The repository must be searchable, downloadable at no cost, and accessible to the public in machine-readable formats that allow unrestricted use, reuse, and automated processing of the data. The department must also provide automated access through standardized application programming interfaces and update the datasets regularly. Within two years of the bill's enactment and annually thereafter, the HHS Secretary must report to Congress on the number and types of datasets available, their update frequency, and any legal, technical, financial, or administrative obstacles preventing publication of additional datasets. The bill affects researchers, public health professionals, healthcare providers, and the general public who seek access to HHS health data for analysis and research purposes.