The POWER Up Act clarifies that the Federal Energy Regulatory Commission has jurisdiction over connecting large electricity consumers directly to the nation's interstate power transmission system. A "large load facility" is defined as any facility or group of related facilities at the same or adjacent locations that demand 100 megawatts or more of electricity, though the Commission can adjust this threshold as needed to protect grid reliability. The legislation requires the Commission to create standardized procedures and agreements for these large industrial connections within 18 months of the law's enactment. The bill does not affect states' existing authority over facility siting, permits, construction, retail electric rates, local power distribution, or power generation. This measure aims to establish clear federal oversight for major industrial electricity consumers while preserving traditional state and local regulatory roles.