The Make Our Streets Safe Again Act directs federal agencies to refocus their approach to homelessness and street crime by prioritizing enforcement of laws against drug use, camping, and loitering, along with expanding civil commitment of individuals with mental illness or substance use disorders who pose dangers to themselves or others. The bill instructs the Attorney General, Secretaries of Health and Human Services, Housing and Urban Development, and Transportation to shift federal grants and resources toward jurisdictions that aggressively enforce these policies and away from "housing first" and "harm reduction" programs. The legislation also requires federal law enforcement to investigate homelessness assistance programs that operate drug consumption sites, tightens requirements for treatment and accountability in federal homelessness programs, and mandates data collection from homeless individuals for law enforcement purposes. The bill contains no explicit funding allocation or timeline but directs agencies to redirect existing discretionary grant programs and federal resources to implement these new priorities immediately.