This bill establishes the Heart Security Foundation, a nonprofit corporation chartered by the federal government to accelerate cardiovascular research in the United States. The foundation will raise private donations and apply for federal research grants to provide targeted funding to research institutions, with a particular focus on biomarker research related to early-onset heart disease. A five-member board of directors, appointed by the director of the National Institutes of Health, will oversee the foundation's operations, and at least three members must have expertise in cardiovascular research, genetic biomarkers, clinical studies, or related fields. The foundation is prohibited from engaging in political advocacy, community organizing, public messaging campaigns, or operating as a health care provider, and it must submit annual reports to Congress detailing funds raised, grants awarded, and research outcomes. No specific federal funding is allocated in the bill, as the foundation will primarily rely on private donations and competitive federal research grants.