The SCREENS Act directs the National Coordinator for Health Information Technology to create a standardized, computerized framework for cancer screening recommendations within one year of enactment. This framework will consolidate guidance from major health organizations including the U.S. Preventive Services Task Force and National Cancer Institute, and will be made available in a machine-readable format so that electronic health records and other health technology systems can use it to help patients understand their screening needs. Within five years, the bill requires that certified electronic health records include technology to display each patient's cancer screening status based on their age, sex, and risk factors, while maintaining strict privacy protections. The bill also directs the Secretary of Health and Human Services to issue guidance within two years encouraging health insurance plans, including Medicaid, Medicare Advantage, and Affordable Care Act plans, to adopt these cancer screening technologies. Additionally, the Patient-Centered Outcomes Research Institute is authorized to fund research and pilot projects to test and implement these computerized screening recommendations in clinical settings.