The END 7-OH Act would classify synthetic 7-hydroxymitragynine as a Schedule I controlled substance under federal law, placing it in the same legal category as drugs like heroin and LSD. The bill specifically targets synthetic versions of this chemical compound while explicitly exempting naturally occurring 7-hydroxymitragynine found in kratom, a plant whose leaves are commonly used in dietary supplements and traditional medicines. This legislation would affect manufacturers, distributors, and users of products containing synthetic 7-hydroxymitragynine, making possession and sale of these synthetic forms illegal under federal law. The bill does not specify funding or implementation timelines. The measure was introduced on March 19, 2026, and referred to the House Energy and Commerce Committee and Judiciary Committee for consideration.