The 21st Century Entrepreneurship Act directs the Small Business Administration to develop a curriculum for retired business executives in the SCORE program to teach entrepreneurship to students at community learning centers, particularly those serving disadvantaged youth. The bill requires the SBA to work with education specialists, business groups, and organizations serving underrepresented children when creating the curriculum, and to collaborate with the Department of Education on implementing the program. The legislation encourages SCORE volunteers to work alongside other small business development programs and women's and minority business centers when teaching entrepreneurship. The bill mandates that the SBA submit reports to Congress every two years starting within one year of enactment, documenting how many students were reached, how funds were used, and any barriers or improvements needed for the program. No specific funding amounts are authorized in the bill.